BioNano與紐約基因組研究中心開始戰(zhàn)略性合作

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BioNano與紐約基因組研究中心開始戰(zhàn)略性合作

2013年7月8日，BioNano Genomics與紐約基因組研究中心（New York Genome Center Enter, NYGC）正式宣布雙方成為戰(zhàn)略合作伙伴，同時NYGC購買了一套Irys™系統(tǒng)。

全球商業(yè)運營副總裁Todd Dickinson教授說：“紐約基因組中心是北美最大、最雄心勃勃的基因組學和生物信息學機構(gòu)之一，我們也很高興他們能把我們的系統(tǒng)平臺囊括其中�！薄皩τ贐ioNano來說是一個重要的里程碑，證明自己有能力提供一個成熟的商業(yè)技術(shù)，來解決像NYGC這樣一個大的研究中心對長片段基因組信息的需求。有了Irys系統(tǒng)提供的最先進長片段讀取技術(shù)，NYGC可以加快轉(zhuǎn)化研究并最終實現(xiàn)改善人類健康的使命�！�

NYGC成立于2010年，通過對基因組數(shù)據(jù)和資源的整合既加快了生物醫(yī)學研究速度又提高了臨床護理質(zhì)量。在2012年，NYGC推出全面的基因組解決方案，包含高通量測序，生物信息學分析與數(shù)據(jù)管理在內(nèi)的個性化定制服務(wù)。今年晚些時候?qū)⒃诼D設(shè)立永久總部，開放其獨立的非盈利研究中心的先進設(shè)施。該機構(gòu)將提供給研究人員一個能接觸最先進的測序技術(shù)和生物信息學的工作環(huán)境。

NYGC的科學主管，總裁Robert B. Darnell博士說：“創(chuàng)新和尖端技術(shù)是我們給紐約市和外面的研究者提供高質(zhì)量的基因組測序和生物信息學服務(wù)的關(guān)鍵所在�！� “基因組學的研究人員和臨床醫(yī)生需要準確全面的基因組結(jié)構(gòu)變異檢測，來實現(xiàn)精確的疾病檢測與診斷，從而改善全世界患者的療效�！�

基因組測序技術(shù)經(jīng)常被描述為短，中，長測序。短，中測序技術(shù)依賴于DNA片段的推斷信息。長測序技術(shù)，像Irys系統(tǒng)，保留原始的基因組結(jié)構(gòu)，它可以更深入的了解基因組變化。直接可視化的基因組裝和高通量的單分子成像能力使結(jié)構(gòu)變異的全面檢測得以實現(xiàn)，能顯著改善基因組組裝，并最終得到單倍型。

科學副主任Kevin V. Shianna博士指出：“我們定期評估對基因組學和生物信息學有重大應(yīng)用的新技術(shù)，在創(chuàng)新、需求和商業(yè)準備的基礎(chǔ)上評價這些系統(tǒng)�！薄癇ioNano的Irys系統(tǒng)提供的長片段基因組信息對于我們現(xiàn)有的測序技術(shù)是個極大的補充，使我們能夠觀察到更完整的基因組變異情況�！�

Mon Jul 8, 2013 8:00am EDT

BioNano Genomics and New York Genome Center Enter Into a Strategic Collaboration

PR Newswire

SAN DIEGO and NEW YORK, July 8, 2013 /PRNewswire/ -- BioNano Genomics and the New York Genome Center (NYGC) announced today a strategic partnership between the two institutions that includes the purchase of an Irys™ System by NYGC.

"The New York Genome Center is creating one of the largest and most ambitious genomics and bioinformatics facilities in North America, and we are thrilled to have them bring our platform in-house," said Todd Dickinson, Ph.D., vice president, Global Commercial Operations. "For BioNano, demonstrating the ability to deliver a commercial-ready technology that can address the long-range information needs of a premier genome center like NYGC marks an important milestone. With their Irys System, the NYGC will now provide their direct research community with the most advanced long-read commercial technology to accelerate translational research and ultimately improve human health, consistent with the mission of this new center."

NYGC was founded in 2010 to speed biomedical research and improve clinical care through a collaborative approach to genomic data and resources. In 2012, NYGC launched its Integrated Genomic Solutions, custom-built services incorporating high-throughput sequencing, bioinformatics analysis, and data management. Later this year, the independent non-profit will open its state-of-the-art facility and permanent headquarters in lower Manhattan. The facility will provide a collective workspace available to researchers to access the most advanced technologies and sequencing and bioinformatics leadership.

"Innovation and cutting-edge technologies are key to our vision of providing high quality genomics sequencing and bioinformatics services to researchers in New York City and beyond," said Robert B. Darnell, M.D., Ph.D., president and scientific director of NYGC. "Genomics researchers and clinicians need accurate, comprehensive detection of genomic structural variation and to finish genome assemblies to accurately detect and diagnose diseases and improve treatments for patients around the world."

Genomic sequencing technologies are often described as short-, medium-, or long-read. Short- and medium-read technologies rely on inferring information from short fragments of DNA. Long-read technologies, like the Irys System, preserve the native genomic structure, which provides deeper insights into genome variations. The ability to directly visualize the genome with high-throughput single molecule imaging enables the comprehensive detection of structural variation, significantly improved genome assemblies, and ultimately haplotype phasing.

"At NYGC, we regularly assess new technologies that have significant applications for genomics and bioinformatics and evaluate these systems based on innovation, need, and commercial readiness," said Kevin V. Shianna, Ph.D., Deputy Scientific Director, Sequencing. "The long-range genomic information from BioNano's Irys System is highly complementary to our existing sequencing technologies and allows us to achieve a significantly more complete view of the genome and its variation."

About the New York Genome Center

Founded in August 2010, the New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics research facilities in North America, while integrating sequencing, bioinformatics, data management, and cutting-edge genomics research. For more information, visit www.nygenome.org.

About Irys

Irys makes it possible to routinely and accurately detect genomic structural variation and to finish genome assemblies. The fully automated Irys benchtop instrument uses the IrysChip to uncoil and confine long DNA molecules in proprietary Nanochannel Arrays™ where they are uniformly linearized in a highly parallel display for high-resolution, single-molecule imaging. Irys does not employ DNA fragmentation or amplification, which are typical with next-generation sequencing. The result is sequence information over extremely long "reads" ranging from hundreds of kilobases to a megabase, where the sample's valuable structural information is preserved. Irys makes it possible for researchers to directly observe structural variants including replications, deletions, translocations and inversions.

About BioNano Genomics

Headquartered in San Diego, BioNano Genomics is delivering an altogether better way of gaining a fully informed understanding of genomes. The Company's platform provides researchers and clinicians the most comprehensive, organized and actionable picture of a genome with unprecedented insights into how the individual components of genomes are ordered, arranged, and interact with each other. BioNano Genomics works with institutions in life science, translational research, molecular diagnostics and personalized medicine. The Company is supported by private investors and grant funding from genomics programs at federal agencies, including the NIH and NIST-ATP.

www.BioNanoGenomics.com

Notes: BioNano Genomics is a trademark of BioNano Genomics, Inc. Any other names of actual companies, organizations, entities, products or services may be the trademarks of their respective owners.

SOURCE BioNano Genomics

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