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ADRA2腎上腺素能受體2抗體
英文名稱:ADRA2總訪問:256
國產(chǎn)/進口:國產(chǎn)半年訪問:13
產(chǎn)地/品牌:bioss產(chǎn)品類別:抗體
規(guī)       格:bs-1062R 最后更新:2017-5-3
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CAS   號:
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產(chǎn)品編號 bs-1062R
英文名稱 ADRA2
中文名稱 ADRA2腎上腺素能受體2抗體
別    名 alpha-2A adrenergic receptor; alpha 2a Adrenergic Receptor; ADRA2A; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32; RATRG20; RG20; Adrenergic alpha 2A receptor; Alpha 2AAR subtype C10; OTTHUMP00000058849; ADA2A_HUMAN; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR.
規(guī)格價格 0.1ml/580元 購買    0.2ml/960元 購買    
說 明 書 0.1ml  0.2ml  
研究領域 神經(jīng)生物學  生長因子和激素  細胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADRA2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 產(chǎn) 商 BIOSS
PubMed PubMed
產(chǎn)品介紹 background:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha 2A, alpha 2B, and alpha 2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha 2A and alpha 2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha 2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha 2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha 2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq].

Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Subcellular Location:
Cell membrane.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily.
ADRA2A sub-subfamily.

Gene ID:
150

Database links:

Entrez Gene: 150 Human

Entrez Gene: 11551 Mouse

Entrez Gene: 25083 Rat

Entrez Gene: 266750 Zebrafish

Omim: 104210 Human

SwissProt: P08913 Human

SwissProt: Q01338 Mouse

SwissProt: P22909 Rat

SwissProt: Q1L8Y8 Zebrafish

SwissProt: Q90WY4 Zebrafish

Unigene: 249159 Human

Unigene: 235195 Mouse

Unigene: 170171 Rat

Unigene: 30878 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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