Octet分子互作應(yīng)用文獻(xiàn)：國(guó)內(nèi)發(fā)表匯總

目前國(guó)內(nèi)高校和科研院所等單位的Octet互作儀已有不下幾百臺(tái)。那這些單位的使用情況如何？是否產(chǎn)生了很多科研成果呢？廢話少說(shuō)，數(shù)據(jù)說(shuō)話！

陳老濕發(fā)現(xiàn)截至2021年第一季度，國(guó)內(nèi)單位發(fā)表的文章就有100多篇引用了Octet數(shù)據(jù)的（約占全球Octet文章總數(shù)20%）。去除掉一些預(yù)印版文章、綜述以及未能下載的文章，陳老濕嘔心瀝血的統(tǒng)計(jì)了其中80多篇文章的單位以及應(yīng)用（所有文章在文末列出）。

文章發(fā)表單位統(tǒng)計(jì)

單位	文獻(xiàn)數(shù)	單位	文獻(xiàn)數(shù)
中國(guó)水生生物研究所	1	海正藥業(yè)	1
吉林大學(xué)	1	上海交通大學(xué)	2
南京農(nóng)大	1	廣西科技大學(xué)	1
信達(dá)生物	1	中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院	1
南昌大學(xué)	1	上海市食品藥品檢驗(yàn)研究院	1
中國(guó)科學(xué)院蘇州生物醫(yī)學(xué)工程技術(shù)研究所	1	中國(guó)科學(xué)技術(shù)大學(xué)	1
廈門大學(xué)化學(xué)化工學(xué)院	1	上海生物化學(xué)與細(xì)胞研究所	3
北京協(xié)和醫(yī)學(xué)院	1	中南民族大學(xué)	1
昆明醫(yī)科大學(xué)第一附屬醫(yī)院	1	國(guó)家納米科學(xué)中心	1
上海巴斯德所	2	上海科技大學(xué)	2
北大深圳醫(yī)院	1	東陽(yáng)光生物科技	1
西湖大學(xué)	2	華東師范大學(xué)	1
青島大學(xué)	1	鄭州大學(xué)	4
寧波大學(xué)	2	青島農(nóng)業(yè)大學(xué)	1
云南農(nóng)業(yè)大學(xué)	1	杭州醫(yī)科學(xué)院	1
北京熱帶醫(yī)學(xué)研究所	1	濱州醫(yī)學(xué)院	1
沈陽(yáng)藥科大學(xué)	1	華東理工大學(xué)	2
華西醫(yī)院	2	復(fù)旦大學(xué)	1
中山大學(xué)癌癥研究中心	2	東北農(nóng)業(yè)大學(xué)	1
吉林醫(yī)科大學(xué)	1	南方醫(yī)科大學(xué)	1
深圳大學(xué)	1	中山大學(xué)第五附屬醫(yī)院	1
上海醫(yī)工院	1	西京醫(yī)院	1
中國(guó)藥科大學(xué)	5	華中科技大學(xué)	1
三葉草生物醫(yī)藥	2	浙江大學(xué)藥學(xué)院	1
廣州中醫(yī)藥大學(xué)	1	曲阜師范大學(xué)	1
江南大學(xué)	1	南京醫(yī)科大學(xué)	1
上海藥物所	1	蛋白質(zhì)中心	1
武漢大學(xué)	1	長(zhǎng)春理工大學(xué)	1
軍事科學(xué)研究院（沈倍奮，陳薇組）	2	廣西大學(xué)	1
麗水學(xué)院	1	高能物理研究所	1
第三軍醫(yī)大學(xué)	1	上海植物逆境生物學(xué)研究中心	1

 
 
第一季度文章發(fā)表單位共有60多個(gè)，基本都是Octet現(xiàn)有客戶。涉及藥物研發(fā)、植物、腫瘤機(jī)理等各個(gè)方向。其中中國(guó)藥科大學(xué)、鄭州大學(xué)、上海生物化學(xué)與細(xì)胞研究所在2021年第一季度發(fā)表了至少3篇文章，還有其他11個(gè)單位發(fā)表了至少2篇文章。考慮到還有其他文章也是在上海生物化學(xué)與細(xì)胞研究所中完成的（比如上海巴斯德所），所以是當(dāng)之無(wú)愧的最多產(chǎn)Octet客戶。
 
陳老濕幾年前寫過(guò)這個(gè)單位的介紹，具體可以看 《如何把高端儀器玩的溜：專訪中科院生物化學(xué)與細(xì)胞生物學(xué)研究所》。
 
 
可見，文章的主要應(yīng)用在于小分子、蛋白（含抗體）等物質(zhì)的互作，占了近7成。特別是小分子化合物的相關(guān)文章達(dá)到了3成，足可以說(shuō)明Octet在檢測(cè)小分子化合物上的表現(xiàn)有了長(zhǎng)足進(jìn)步。
另外，檢測(cè)物質(zhì)還有細(xì)菌、多糖、脂質(zhì)體和納米顆粒，再次證明Octet在可檢測(cè)樣品種類范圍方面處于同類儀器領(lǐng)先地位。
 
  1  良好的技術(shù)支持
比如西湖大學(xué)（Octet RED96e）、寧波大學(xué)(Octet K2)和華西醫(yī)院(Octet K2)都是2020年年中完成裝機(jī)培訓(xùn)的儀器，使用僅半年就發(fā)表了至少2篇文章。這個(gè)成就離不開強(qiáng)大的Octet技術(shù)支持團(tuán)隊(duì)的貢獻(xiàn)。比如華西醫(yī)院，盡管地處成都，Octet的應(yīng)用科學(xué)家在半年里就去了不下5次。此外西湖大學(xué)的設(shè)備基礎(chǔ)培訓(xùn)，由于參與學(xué)員眾多，只能分成4組輪番上陣。雖然我們的培訓(xùn)老師講的口干舌燥，但的確獲得了很好的效果，因此在裝機(jī)培訓(xùn)后的短短2個(gè)月內(nèi)又舉辦了一次針對(duì)性的高級(jí)培訓(xùn)。
 
據(jù)統(tǒng)計(jì)，僅2020年下半年，各種基礎(chǔ)培訓(xùn)班、再培訓(xùn)、在線培訓(xùn)的次數(shù)達(dá)到三十幾場(chǎng)，培養(yǎng)了一批技術(shù)精湛的Octet使用者。（本周第三條推送有Octet培訓(xùn)報(bào)名，大家走過(guò)路過(guò)不要錯(cuò)過(guò)！）
2  儀器操作簡(jiǎn)單易學(xué)，無(wú)需繁瑣日常維護(hù)
Octet系統(tǒng)擯棄了繁瑣的微流路設(shè)計(jì)，使用獨(dú)有的生物傳感器浸入即讀檢測(cè)方式，待測(cè)樣品亦無(wú)需特殊預(yù)處理。即使在使用中發(fā)生操作失誤，也不會(huì)導(dǎo)致儀器的損傷，只需重新啟動(dòng)一下就可以繼續(xù)放心使用！儀器使用后無(wú)需繁瑣的維護(hù)工作，只要定期用酒精清潔一下探頭即可。

3  可檢測(cè)樣本種類范圍廣泛，定量化的分子互作表征技術(shù)
上文的應(yīng)用分布充分展示了可用于Octet檢測(cè)的樣品種類之寬泛，尤其可以滿足某些交叉學(xué)科的要求。由于ELISA和Pulldown等傳統(tǒng)方法一般都有洗滌步驟，導(dǎo)致一些解離快結(jié)合弱的互作無(wú)法檢測(cè)；而且操作較為繁瑣，測(cè)試一對(duì)樣品的結(jié)合反應(yīng)往往要花費(fèi)1-2天時(shí)間，重復(fù)性也往往不甚理想。當(dāng)實(shí)驗(yàn)有效性存在問(wèn)題時(shí)，也難于發(fā)現(xiàn)原因所在。Octet系統(tǒng)不僅可以彌補(bǔ)這些缺點(diǎn)，還可以增加互作檢測(cè)效率與可信度，滿足用戶高通量檢測(cè)的需求，在短時(shí)間內(nèi)同時(shí)平行檢測(cè)多對(duì)樣品的相互作用分析。
 


陳老濕曰 
今天就寫到這里吧，陳老濕要繼續(xù)去回復(fù)客戶的郵件和微信了。在陳老濕下一周的微信發(fā)布中，我們會(huì)對(duì)這些國(guó)內(nèi)文章進(jìn)行“頒獎(jiǎng)”，敬請(qǐng)期待！
  
最后向奮斗在一線的科研工作者致敬！



部分2021年Q1的國(guó)內(nèi)Octet文章（共84篇）
 
In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants.Q Shi, W Guo, Q Shen, J Han, L Lei, L Chen… - Journal of Hazardous …, 2021 - Elsevier

• Rapid label‐free detection of Salmonella enterica with biolayer interferometry.CL Zang, MD Zhang, Y Zhang, YS Li, K Liu… - Journal of Food … - Wiley Online Library
• Insight into the effect of charge regulation on the binding mechanism of curcumin to myofibrillar protein.C Wu, H Dong, P Wang, X Xu, Y Zhang, Y Li - Food Chemistry, 2021 - Elsevier
• The binding epitope of sintilimab on PD-1 revealed by AbMap.M Ma, H Qi, C Hu, Z Xu, F Wu, N Wang… - Acta Biochimica et …, 2021 - academic.oup.com
• Tandem Nanobody: a feasible way to improve the capacity of affinity chromatography.Y Huang, J Fu, Y Zhong, W Shuai, H Zhang, Y Li… - … of Chromatography B, 2021 - Elsevier
• Construction of CRISPR‐BLI platform for real‐time, sensitive, and specific DNA detection.S Qiao, Z Liu, H Li, X He, H Pan, G Yuzhou - ChemBioChem, 2021 - Wiley Online Library
• Development of a Tetravalent T-Cell Engaging Bispecific Antibody Against Glypican-3 for Hepatocellular Carcinoma.L Yu, N Huang, H Sun, X Yang, Y Fu… - Journal of …, 2021
• Suramin Targets the Conserved Ligand-Binding Pocket of Human Raf1 Kinase Inhibitory Protein.C Guo, Z Wu, W Lin, H Xu, T Chang, Y Dai, D Lin - Molecules, 2021 - mdpi.com
• Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase.Q Li, D Yi, X Lei, J Zhao, Y Zhang, X Cui, X Xiao… - … Pharmaceutica Sinica B, 2021 - Elsevier
• A novel peptide identified from skin secretions of Bombina maxima possesses LPS-neutralizing activity.C Guo, J Li, WH Lee, H Li, J Shen, B Zhang - Biochemical and Biophysical …, 2021 - Elsevier
• Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques.R Yang, Q Liu, W Pang, F Gao, H Liang, W Zhang… - Vaccine, 2021 - Elsevier
• Synthesis of RNA-based gene regulatory devices for redirecting cellular signaling events mediated by p53.X Huang, M Wang, Y Liu, Y Gui - Theranostics, 2021 - ncbi.nlm.nih.gov
• Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection.L Guo, W Bi, X Wang, W Xu, R Yan, Y Zhang, K Zhao… - Cell research, 2021 - nature.com
• Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the identification of novel SH2 superbinders.S Li, Y Zou, D Zhao, Y Yin, J Song, N He, H Liu… - Protein …, 2021 - Wiley Online Library
• Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1.W Wu, H Han, J Liu, M Tang, X Wu, X Cao… - … medicine and cellular …, 2021 - hindawi.com
• (-)-Epigallocatechin-3-gallate inhibits osteoclastogenesis by blocking RANKL–RANK interaction and suppressing NF-κB and MAPK signaling pathways.H Xu, T Liu, Y Jia, J Li, L Jiang, C Hu, X Wang… - International …, 2021 - Elsevier
• N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells.N Song, L Chen, X Ren, NR Waterfield, J Yang… - PLoS …, 2021 - journals.plos.org
• Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus.H Su, X Ye, DC Freed, L Li, Z Ku, W Xiong… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
• Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and …T She, Q Shi, Z Li, Y Feng, H Yang, Z Tao, H Li… - Theranostics, 2021 - ncbi.nlm.nih.gov
• Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates.YF Kang, C Sun, Z Zhuang, RY Yuan, Q Zheng, JP Li… - ACS …, 2021 - ACS Publications
• Construction and application of a human scFv phage display library based on Cre‑LoxP recombination for anti‑PCSK9 antibody selection.Y Dong, F Meng, Z Wang, T Yu… - International …, 2021 - spandidos-publications.com
• Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.S Xiao, Y Lu, Q Wu, J Yang, J Chen, S Zhong… - International Journal of …, 2021 - Elsevier
• Long-Acting Human Interleukin 2 Bioconjugate Modified with Fatty Acids by Sortase A.M Qian, Q Zhang, J Lu, J Zhang, Y Wang… - Bioconjugate …, 2021 - ACS Publications
• Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor.BY Zhang, L Zhang, YM Chen, X Qiao… - British Journal of …, 2021 - Wiley Online Library
• S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates.JG Liang, D Su, TZ Song, Y Zeng, W Huang… - Nature …, 2021 - nature.com
• Structure-function relationship of bifunctional XynA.W Xie, Q Yu, R Zhang, Y Liu, R Cao, S Wang… - Authorea …, 2021 - authorea.com
• AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells.S Wang, Z Qiu, Y Hou, X Deng, W Xu, T Zheng, P Wu… - Cell research, 2021 - nature.com
• Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding.J Zhou, F Wang, J Chen, R Yang, Y Chen, D Gu… - Pharmacological …, 2021 - Elsevier
• A novel humanized Frizzled-7-targeting antibody enhances antitumor effects of Bevacizumab against triple-negative breast cancer via blocking Wnt/β-catenin …W Xie, H Zhao, F Wang, Y Wang, Y He, T Wang… - Journal of Experimental …, 2021 - Springer
• LT-171-861, a novel FLT3 inhibitor, shows excellent preclinical efficacy for the treatment of FLT3 mutant acute myeloid leukemia.Z Yu, J Du, H Hui, S Kan, T Huo, K Zhao, T Wu… - Theranostics, 2021
• Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation.KL Ji, YY Fan, HH Kuok, QF Liu, T Li, JM Yue - CCS Chemistry, 2021
• Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensorK Wang, H Wang, C Li, Z Yin, R Xiao… - Science …, 2021 - advances.sciencemag.org
• A single nucleotide mutation drastically increases the expression of tumor-homing NGR-TNFα in the E. coli M15-pQE30 system by improving gene transcription.Applied Microbiology and Biotechnology volume 105, pages1447–1460(2021)
• Identification of a novel protective human monoclonal antibody, LXY8, that targets the key neutralizing epitopes of staphylococcal enterotoxin B.N Hu, C Qiao, J Wang, Z Wang, X Li, L Zhou… - Biochemical and …, 2021 - Elsevier
• The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264. 7 macrophages.J Hou, H Liu, H Diao, H Yu - Peptides, 2021 - Elsevier
• Isolation and characterization of charge variants of infliximab biosimilar HS626.JJ Yuan, D Gao, F Hu, Y Shi, ZH Wu, CQ Hu… - … of Chromatography B, 2021 - Elsevier
• Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run.H Qi, M Ma, C Hu, Z Xu, F Wu, N Wang, D Lai… - Molecular & Cellular …, 2021 - Elsevier
• An artemisinin derivative ART1 induces ferroptosis by targeting the HSD17B4 protein essential for lipid metabolism and directly inducing lipid peroxidation.J Xie, G Zhu, M Gao, J Xi, G Chen, X Ma, Y Yan… - CCS …, 2021 - chinesechemsoc.org
• Development of a novel, fully human, anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy.M Xu, G Lei, M Chen, K Wang, W Lv, P Zhang, T Hu… - EBioMedicine, 2021 - Elsevier
• Generation of Dual functional Nanobody-Nanoluciferase Fusion and its potential in Bioluminescence Enzyme Immunoassay for trace Glypican-3 in Serum.S Yu, Z Li, J Li, S Zhao, S Wu, H Liu, X Bi, D Li… - Sensors and Actuators B …, 2021 - Elsevier
• Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.Q Zhang, X Wu, J Zhou, L Zhang, X Xu, L Zhang… - European Journal of …, 2021 - Elsevier
• Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fcγ Receptor-Dependent and-Independent Pathways.L Yu, X Liu, X Ye, W Su, X Zhang, W Deng, J Luo… - Mbio, 2021 - Am Soc Microbiol
• Biosimilar or Not: Physicochemical and Biological Characterization of MabThera and Its Two Biosimilar Candidates.H Wang, L Wu, C Wang, J Xu, H Yin… - ACS Pharmacology & …, 2021 - ACS Publications
• Characterization of SARS-CoV-2-specific antibodies in COVID-19 patients reveals highly potent neutralizing IgA.W Zeng, H Ma, C Ding, Y Yang, Y Sun… - Signal transduction and …, 2021 - nature.com
• Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.D Zhu, S Li, C Chen, S Wang, J Zhu, L Kong… - Pharmacological …, 2021 - Elsevier
• Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.C Xu, Y Wang, C Liu, C Zhang, W Han… - Science …, 2021 - advances.sciencemag.org
• Unveiling the Disaccharide-Branched Glycosaminoglycan and Anticoagulant Potential of Its Derivatives.R Yin, L Zhou, N Gao, L Lin, H Sun, D Chen… - …, 2021 - ACS Publications
• Cryo-EM structure of S-Trimer, a subunit vaccine candidate for COVID-19.J Ma, D Su, Y Sun, X Huang, Y Liang, L Fang… - Journal of …, 2021 - Am Soc Microbiol
• Engineering a Self-Navigated MnARK Nanovaccine for Inducing Potent Protective Immunity against Novel Coronavirus.Y Wang, Y Xie, J Luo, M Guo, X Hu, X Chen, Z Chen… - Nano today, 2021 - Elsevier
• Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARs.P Ma, P Ren, C Zhang, J Tang, Z Yu, X Zhu… - Advanced …, 2021 - Wiley Online Library
• Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.C Zhang, Y Wang, Y Zhu, C Liu, C Gu, S Xu… - Nature …, 2021 - nature.com
• Junctional and somatic hypermutation-induced CX 4 C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly ….C Yi, J Xia, L He, Z Ling, X Wang, Y Yan… - Cellular & molecular …, 2021 - nature.com
• Structural insights into the co-evolution of IL-2 and its private receptor in fish.J Wang, W Wang, J Xu, Z Jia, Q Liu, X Zhu, C Xia… - Developmental & …, 2021 - Elsevier
• A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis.Q Pan, S Lin, Y Li, L Liu, X Li, X Gao, J Yan, B Gu… - EBioMedicine, 2021 - Elsevier
• Tetanus vaccine-induced human neutralizing antibodies provide full protection against neurotoxin challenge in mice.G Zhang, R Yu, X Chi, Z Chen, M Hao, P Du… - International …, 2021 - Elsevier
• A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression.Y He, W Kan, Y Li, Y Hao, A Huang… - Clinical and …, 2021 - Wiley Online Librar
• Identification of novel 1, 3-diaryl-1, 2, 4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity.XH Zhang, HQ Kang, YY Tao, YH Li, JR Zhao… - European Journal of …, 2021 - Elsevier
• Molecular Assessment of the Toxic Mechanism of the Latest Neonicotinoid Dinotefuran with Glutathione Peroxidase 6 from Arabidopsis thaliana.Y Xie, X Hou - Journal of Agricultural and Food Chemistry, 2021 - ACS Publications
• Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways.ZH Ying, HM Li, WY Yu, CH Yu - Journal of Inflammation Research, 2021
• Direct interactions between cationic liposomes and bacterial cells ameliorate the systemic treatment of invasive multidrug-resistant Staphylococcus aureus infections.R Guo, Y Liu, K Li, B Tian, W Li, S Niu… - … , Biology and Medicine, 2021 - Elsevier
• RegX3-Mediated Regulation of Methylcitrate Cycle in Mycobacterium smegmatis.JF Pei, N Qi, YX Li, J Wo, BC Ye - Frontiers in microbiology, 2021 - frontiersin.org
• Immunization with a Self-Assembled Nanoparticle Vaccine Elicits Potent Neutralizing Antibody Responses against EBV Infection.YF Kang, X Zhang, XH Yu, Q Zheng, Z Liu, JP Li… - Nano Letters, 2021 - ACS Publications
• Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody
• Z Xu, J Gao, J Yao, T Yang, D Wang, C Dai, Y Ding - FEBS Open Bio - Wiley Online Library
• Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4 (3H)-one derivatives as novel USP7 inhibitors.P Li, Y Liu, H Yang, HM Liu - European Journal of Medicinal Chemistry, 2021 - Elsevier
• Molecular Properties of Flammulina velutipes Polysaccharide–Whey Protein Isolate (WPI) Complexes via Noncovalent Interactions.J Shang, M Liao, R Jin, X Teng, H Li, Y Xu, L Zhang… - Foods, 2021 - mdpi.com
• Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID‐19 by Blocking SARS‐CoV‐2 Spike Protein‐Mediated Membrane Fusion.C Yang, X Pan, Y Huang, C Cheng, X Xu… - Advanced …, 2021 - Wiley Online Library
• Molecular mechanism for vitamin C-derived C 5-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1.W Li, T Zhang, M Sun, Y Shi, XJ Zhang, GL Xu… - Nature …, 2021 - nature.com
• Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.W Zhou, C Xu, G Dong, H Qiao, J Yang, HM Liu… - European Journal of …, 2021 - Elsevier
• Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes.Z Zhou, C Huang, Z Zhou, Z Huang, L Su, S Kang… - Iscience, 2021 - Elsevier
• A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species.Z Zhou, H Tang, W Wang, L Zhang, F Su, Y Wu, L Bai… - Cell Discovery, 2021 - nature.com
• A novel human anti-TIGIT monoclonal antibody with excellent function in eliciting NK cell-mediated antitumor immunity.D Han, Y Xu, X Zhao, Y Mao, Q Kang, W Wen… - Biochemical and …, 2021 - Elsevier
• Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1.XJ Dai, Y Liu, LP Xue, XP Xiong, Y Zhou… - Journal of Medicinal …, 2021 - ACS Publications
• LysR Family regulator LttR Controls Conjugated Linoleic Acid Production by Directly Activating the cla Operon in Lactobacillus plantarum.XX Liu, ZQ Xiong, GQ Wang, LF Wang… - Applied and …, 2021 - Am Soc Microbiol
• Development and functional characterization of novel fully human anti‐CD19 chimeric antigen receptors for T‐cell therapy.Z Dai, X Hu, X Jia, J Liu, Y Yang, P Niu, G Hu… - Journal of Cellular … - Wiley Online Library
• Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays.J Pang, C Shen, W Zhou, Y Wang, L Shan… - Acta Pharmacologica …, 2021 - nature.com
• Ebselen-Agents for Sensing, Imaging and Labeling: Facile and Full-Featured Application in Biochemical Analysis.J Zhang, L Yang, Y Wang, T Cao, Z Sun… - ACS Applied Bio …, 2021 - ACS Publications
• Mycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription.N Qi, GL She, W Du, BC Ye - Frontiers in microbiology, 2021 - frontiersin.org
• Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance.H Zhang, Y Zhang, J Dong, B Li, C Xu, M Wei… - Molecular Therapy …, 2021 - Elsevier
• A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2.H Yao, H Cai, T Li, B Zhou, W Qin, D Lavillette… - PLoS …, 2021 - journals.plos.org
• Characterization of a LuxR repressor for 3, 17β-HSD in Comamonas testosteroni ATCC11996.Y Ji, J Yang, L Gao, G Xiong, Y Yu, Y Zhang - Chemico-Biological …, 2021 - Elsevier
• Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review.H Li, Q Yuan, K Lv, H Ma, C Gao, Y Liu, S Zhang… - Carbohydrate …, 2021 - Elsevier
• Interaction of Humic Acid with Graphene Oxide: Relation to Antibacterial Activities Against Escherichia coli.H Yu, R Chu, X Li, B Wang, W Chen, S Zhou… - … of Nanoscience and … - ingentaconnect.com
• Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.Plant Cell. 2021 Jan 25
• Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection.ACS Nano 2021