斑馬魚(yú)用于識(shí)別癌變和腫瘤進(jìn)展的研究

研究顯示，斑馬魚(yú)和人類基因組的同源性高達(dá) 70% 以上。斑馬魚(yú)的基因組與人類疾病相關(guān)基因的相似性高達(dá) 80%。和人相比，斑馬魚(yú)的生理機(jī)能非常保守 (有時(shí)候比嚙齒類動(dòng)物更保守)，如心臟電生理學(xué)。

青鳉個(gè)體小、繁殖快、近交品系多、突變體多，有完整的基因組序列，與大多數(shù)魚(yú)類不同，青鳉具有二倍體染色體結(jié)構(gòu)，是唯一擁有雄性性別決定基因和雌性決定基因的脊椎動(dòng)物。多種干細(xì)胞系的建立為研究基因功能所需的細(xì)胞生物學(xué)研究提供了良好的平臺(tái)。ZFN 和 TALENs，尤其是 CRISP Cas9 技術(shù)在青鳉中均已成功應(yīng)用。越來(lái)越多的學(xué)者以青鳉為模式物種進(jìn)行生殖細(xì)胞發(fā)育等功能研究。

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