T Cell Receptor 信號通路圖

The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains (shown here) or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell''s transcriptional machinary upon engagement of the receptor.

 

本信號轉導涉及的信號分子主要包括：
TCR，CD30，Zap-70，LAF-1，Actinin，Talin，SOS，GRB2，LAT，PLCγ1，NCK，SLP76，ADAP，Vav，WASP，Rac，cdc42，DIgh1，CD4，CD45，CD28，Lck，PI3K，CaM，Calclneurin，CaMKIV，Calpain，IP3R，PIP2，DAG，RasGRP，Ras，Raf，MEK1，MEK2，Erk1，Erk2，CREB，NFAT，TAK1，MEKK1，MKK4，MKK7，JNK，JNK2，MAPK，P38，PDK1，PKCθ，c-Cbl，mMALT1，Bcl10，Carma1，TAK1，IKK，Rel，IκB，NF-κB，mTORC1，F(xiàn)os，Jun等。

 

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