第二屆廣州核酸國際論壇 議程盛大公布
主題：Nucleic Acids Translational Research & Therapeutics (siRNA, miRNA, lncRNA, antisense, CRISPR)
第二屆廣州核酸國際論壇（CNAF）以核酸轉(zhuǎn)化研究與治療為主題，旨在推動核酸研究和治療藥物的發(fā)展，加強(qiáng)中國與國際的交流合作，促進(jìn)中國核酸生物產(chǎn)業(yè)的進(jìn)步，展望核酸技術(shù)作為創(chuàng)新藥物第三大發(fā)展引擎的美好前景。
本屆論壇特邀20多位國際頂級科學(xué)家和企業(yè)家參會演講，嘉賓囊括諾貝爾獎得主、世界百強(qiáng)藥企的高級主管、世界頂級學(xué)府的著名教授、核酸制藥上市公司的總裁、核酸治療世界聯(lián)盟主席等，內(nèi)容涵蓋RNAi、microRNA、lncRNA、antisense、mRNA、exon-skipping、CRISPR等核酸技術(shù)最新進(jìn)展，包括從核酸基礎(chǔ)研究到產(chǎn)業(yè)化，從臨床前開發(fā)到臨床研究，并分享去年世界首個核酸藥物成功上市的經(jīng)驗。論壇的召開，將為國內(nèi)科學(xué)家及研究生提供與本領(lǐng)域?qū)W術(shù)權(quán)威面對面交流的難得機(jī)會，為國內(nèi)從事生物制藥的企業(yè)單位提供與世界知名藥企建立合作的紐帶。
我們期待與您相聚美麗羊城，共同迎接核酸治療時代的來臨！
主辦單位：專家聯(lián)誼會生物醫(yī)藥和生命科學(xué)專業(yè)委員會
中國生化與分子生物學(xué)會核糖核酸專業(yè)委員會
中國科學(xué)院廣州生物醫(yī)藥與健康研究院
中山大學(xué)
承辦單位：廣州市銳博生物科技有限公司
開幕主旨演講
Craig Mello教授
美國麻省大學(xué)醫(yī)學(xué)院教授
2006年諾貝爾生理學(xué)或醫(yī)學(xué)獎獲得者
主旨演講
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Troels Koch博士
丹麥Santaris / Roche制藥公司首席技術(shù)官，研發(fā)副總裁
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Ekkehard Leberer教授
法國賽諾菲研發(fā)聯(lián)盟管理高級總監(jiān), IMI COMPACT Consortium常務(wù)董事
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Muthiah Manoharan博士
美國Alnylam制藥公司高級副總裁，新藥開發(fā)負(fù)責(zé)人
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Brett Monia博士
美國Isis 制藥公司高級副總裁
Oligonucleotide Therapeutics Society當(dāng)選主席
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大會擬定議程
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Wed, Nov 5, 2014
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Registration 13:00-18:00
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Thu, Nov 06, 2014 (Day 1)
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Chair
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Mano Manoharan, PhD Senior Vice President, Alnylam Pharmaceuticals, USA
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08:30-08:45
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Introduction
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CNAF Organizing Committee
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08:45-09:30
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Opening Keynote
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Craig Mello, PhD Professor, University of Massachusetts Medical School, HHMI, 2006 Nobel Prize Winner, USA
Title: RNA-guided genome defense and new frontiers in biotech and medicine
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09:30-10:10
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Keynote
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Brett Monia, PhD Senior Vice President, Isis Pharmaceuticals, OTS President, USA
Title: Transforming drug discovery for human therapeutics with antisense technology
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10:10-10:35
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Plenary
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Judy Lieberman, MD, PhD Professor, Program Chair, Harvard Medical School, USA
Title: Targeted gene knockdown to treat cancer
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10:35-10:55
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Tea Break
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10:55-11:20
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Plenary
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Matthew Porteus, MD, PhD Professor, Stanford School of Medicine, CRISPR Therapeutics Founder, USA
Title: Genome editing using engineered nucleases
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11:20-11:45
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Plenary
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Erwei Song, MD, PhD Professor and Vice Dean, Sun Yat-Sen Memorial Hospital, China
Title: BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
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11:45-12:00
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Technology
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Rick Hogrefe, PhD Founder, President and Chief Executive Officer, TriLink BioTechnologies
Title: Designing a mRNA therapeutic suitable for scale up
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12:00-13:30
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Lunch
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13:30-13:35
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Chair
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Brett Monia, PhD Senior Vice President, Isis Pharmaceuticals, OTS President, USA
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13:35-14:15
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Keynote
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Troels Koch, PhD Senior Vice President and Chief Technology Officer, Santaris / Roche, Denmark
Title: LNA antisense – concepts & status
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14:15-14:40
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Plenary
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Dmitry Samarsky, PhD Executive Vice President, Technology Development, RiboBio, China
Title: In vivo delivery of therapeutic oligonucleotides and potential applications for cancer
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14:40-15:05
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Plenary
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Georg Sczakiel, PhD Professor, University of Lübeck, Germany
Title: Target RNA is involved in guide strand loading of Argonaute-2 and siRNA-induced RNA interference
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15:05-15:25
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Tea Break
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15:25-15:50
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Plenary
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Peixuan Guo, PhD Professor, William S. Farish Fund Endowed Chair, University of Kentucky, USA
Title: A new generation of drugs from the emerging field of RNA nanotechnology
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15:50-16:15
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Plenary
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Yi Jin, PhD Executive Vice President, Suzhou Ribo Life Science, China
Title: RNAi based therapeutics for Hepatitis B
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16:15-16:30
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Technology
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Suresh Srivastava, PhD Founder and President, ChemGenes, USA
Title: BMEG oligonucleotides for efficient cellular delivery for therapeutic and molecular biological applications
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16:30-16:55
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Plenary
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David Lewis, PhD Chief Scientific Officer, Arrowhead Research Corporation, USA
Title: Using Dynamic Polyconjugate® (DPC) technology to advance RNAi-based therapeutics
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16:55-17:00
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Day End
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CNAF Organizing Committee
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Fri, Nov 07, 2014 (Day 2)
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09:00-09:05
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Chair
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Troels Koch, PhD Senior Vice President and Chief Technology Officer, Santaris / Roche, Denmark
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09:05-09:45
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Keynote
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Ekkehard Leberer, PhD Professor, Senior Director of R&D Alliance Management, Sanofi, Germany
Title: Nucleic acid therapeutics: opportunities and challenges for innovation in drug development
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09:45-10:10
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Plenary
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William Marshall, PhD President and Chief Executive Officer, Board Director, miRagen Therapeutics, USA
Title: Discovery and development of microRNA targeting therapeutics
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10:10-10:35
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Plenary
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Micky Tortorella, PhD Chief Technology Officer and Vice President for Drug Discovery and Technology Transfer, Guangzhou Institutes of Biomedicine and Health, China
Title: Intra-articular delivery of siRNA-conjugates as new disease modifying osteoarthritis drugs
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10:35-10:55
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Tea Break
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10:55-11:20
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Plenary
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Chengyu Jiang, PhD Professor, Chair, Peking Union Medical College, CAMS, China
Title: Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro
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11:20-11:45
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Plenary
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Marc Lemaitre, PhD Chief Executive Officer, Sirnaomics, USA / China
Title: Improving siRNA therapeutics using polymer-nanoparticle (PNP) delivery: recent pre-clinical results with STP705 against skin scars
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11:45-12:00
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Technology
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Kimo Sanderson Vice President, Asahi Kasei, Japan
Title: Therapeutic oligonucleotides from discovery to development: the importance of proper production and scale up
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12:00-13:30
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Lunch
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13:30-13:35
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Chair
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William Marshall, PhD President, Chief Executive Officer, Board Director, miRagen Therapeutics, USA
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13:35-14:15
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Keynote
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Mano Manoharan, PhD Senior Vice President, Alnylam Pharmaceuticals, USA
Title: Chemical strategies for systemic delivery of RNAi drugs
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14:15-14:40
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Plenary
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Dirk Haussecker, PhD Founder and Curator, RNAi Therapeutics Blog, Germany
Title: RNA therapeutics emerging as major drug discovery engine
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14:40-15:05
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Plenary
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TBD
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15:05-15:20
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Technology
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Carina Andersson, PhD Marketing Head, GE, USA
Title: A manufacturing solution of oligonucleotides
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15:20-15:40
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Tea Break
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15:40-16:05
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Plenary
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Sven Klussmann, PhD Chief Scientific Officer, NOXXON Pharma, Germany
Title: From bench to bedside – the conversion of mirror-image oligonucleotides into therapeutics
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16:05-16:30
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Plenary
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Ryszard Kole, PhD Distinguished Scientist, Professor, Sarepta Therapeutics, USA
Title: Eteplirsen, a phosphorodiamidate morpholino oligonucleotide, as treatment for Duchenne muscular dystrophy (DMD)
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16:30-16:55
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Plenary
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René Thürmer, PhD Deputy Head of the Unit Pharmaceutical Biotechnology, BfArM - Federal Institute for Drugs and Medical Devices, Germany
Title: Regulatory aspects of nucleic acids therapeutics
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16:55-17:15
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Closing Remarks
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Craig Mello, PhD Professor, University of Massachusetts Medical School, HHMI, 2006 Nobel Prize Winner, USA
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會議時間：2014年11月5-7日
會議地點：廣州科學(xué)城翡翠皇冠假日酒店
會議語言：英語
論壇網(wǎng)站：www.cnaf.org.cn（點此注冊）
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