392 次ChIP-seq揭示BRWD3調(diào)控KDM5活性以維持H3K4甲基化水平的表觀機(jī)制應(yīng)用 2023-10-31
組蛋白修飾對(duì)調(diào)控染色質(zhì)結(jié)構(gòu)和基因表達(dá)至關(guān)重要,組蛋白修飾失調(diào)可能導(dǎo)致疾病狀態(tài)和癌癥。染色質(zhì)結(jié)合蛋白BRWD3(Bromodomain and WD repeat-containing protein 3)是Cul4-DDB1 E3泛素連接酶復(fù)合